Aging and saliva: a review of the literature.
Identifieur interne : 000585 ( Main/Exploration ); précédent : 000584; suivant : 000586Aging and saliva: a review of the literature.
Auteurs : A. Vissink [Pays-Bas] ; F K Spijkervet ; A. Van Nieuw AmerongenSource :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 0275-1879 ]
Descripteurs français
- KwdFr :
- Débit sécrétoire (MeSH), Effets secondaires indésirables des médicaments (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Glandes salivaires (anatomie et histologie), Glandes salivaires (métabolisme), Humains (MeSH), Irradiation crânienne (effets indésirables), Mâle (MeSH), Salivation (MeSH), Salive (composition chimique), Salive (métabolisme), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Syndrome de Gougerot-Sjögren (complications), Vieillissement (MeSH), Xérostomie (étiologie).
- MESH :
- anatomie et histologie : Glandes salivaires.
- composition chimique : Salive, Syndrome de Gougerot-Sjögren.
- effets indésirables : Irradiation crânienne.
- métabolisme : Glandes salivaires, Salive.
- étiologie : Xérostomie.
- Débit sécrétoire, Effets secondaires indésirables des médicaments, Facteurs âges, Femelle, Humains, Mâle, Salivation, Sujet âgé, Sujet âgé de 80 ans ou plus, Vieillissement.
English descriptors
- KwdEn :
- Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Aging (MeSH), Cranial Irradiation (adverse effects), Drug-Related Side Effects and Adverse Reactions (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Saliva (chemistry), Saliva (metabolism), Salivary Glands (anatomy & histology), Salivary Glands (metabolism), Salivation (MeSH), Secretory Rate (MeSH), Sjogren's Syndrome (complications), Xerostomia (etiology).
- MESH :
- adverse effects : Cranial Irradiation.
- anatomy & histology : Salivary Glands.
- chemistry : Saliva.
- complications : Sjogren's Syndrome.
- etiology : Xerostomia.
- metabolism : Saliva, Salivary Glands.
- Age Factors, Aged, Aged, 80 and over, Aging, Drug-Related Side Effects and Adverse Reactions, Female, Humans, Male, Salivation, Secretory Rate.
Abstract
It is often assumed that salivary secretion reduces with age. About 25% of the elderly suffer from oral dryness and related complaints. Nevertheless, data on stimulated salivary flow rate in healthy elderly revealed no significant age-related decrease other than a slight decrease of the secretion from the (sero)mucous glands under conditions of minimal or extended stimulation. With regard to salivary gland morphology and composition of saliva, age-related changes have been reported in healthy individuals, too. With increasing age, the number of acini reduces and the amount of fatty and fibrous tissue increases. Moreover, animal studies revealed that the synthesis of proteins is reduced by 60% in advanced years. These data indicate that changes might occur in concentration and/or activity of the organic components of saliva. In human studies, the concentration of sIgA in labial saliva and the concentrations of high-molecular and low-molecular mucins in mucous saliva appeared to be reduced with age. Since sIgA and mucins are important in the immunologic and non-immunologic defense of the oral cavity, both defense systems are reduced in healthy elderly. Analysis of these data suggests that the oral soft tissues may become somewhat more susceptible to environmental factors due to a reduction of the immunological and non-immunological defense systems.
DOI: 10.1111/j.1754-4505.1996.tb00842.x
PubMed: 9084322
Affiliations:
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Le document en format XML
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Van Nieuw Amerongen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996 May-Jun</date><idno type="RBID">pubmed:9084322</idno><idno type="pmid">9084322</idno><idno type="doi">10.1111/j.1754-4505.1996.tb00842.x</idno><idno type="wicri:Area/Main/Corpus">000591</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000591</idno><idno type="wicri:Area/Main/Curation">000591</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000591</idno><idno type="wicri:Area/Main/Exploration">000591</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Aging and saliva: a review of the literature.</title><author><name sortKey="Vissink, A" sort="Vissink, A" uniqKey="Vissink A" first="A" last="Vissink">A. Vissink</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Oral and Maxillofacial Surgery, University Hospital Groningen</wicri:regionArea><wicri:noRegion>University Hospital Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Spijkervet, F K" sort="Spijkervet, F K" uniqKey="Spijkervet F" first="F K" last="Spijkervet">F K Spijkervet</name></author><author><name sortKey="Van Nieuw Amerongen, A" sort="Van Nieuw Amerongen, A" uniqKey="Van Nieuw Amerongen A" first="A" last="Van Nieuw Amerongen">A. Van Nieuw Amerongen</name></author></analytic><series><title level="j">Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</title><idno type="ISSN">0275-1879</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Aging (MeSH)</term><term>Cranial Irradiation (adverse effects)</term><term>Drug-Related Side Effects and Adverse Reactions (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Saliva (chemistry)</term><term>Saliva (metabolism)</term><term>Salivary Glands (anatomy & histology)</term><term>Salivary Glands (metabolism)</term><term>Salivation (MeSH)</term><term>Secretory Rate (MeSH)</term><term>Sjogren's Syndrome (complications)</term><term>Xerostomia (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Débit sécrétoire (MeSH)</term><term>Effets secondaires indésirables des médicaments (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Glandes salivaires (anatomie et histologie)</term><term>Glandes salivaires (métabolisme)</term><term>Humains (MeSH)</term><term>Irradiation crânienne (effets indésirables)</term><term>Mâle (MeSH)</term><term>Salivation (MeSH)</term><term>Salive (composition chimique)</term><term>Salive (métabolisme)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Syndrome de Gougerot-Sjögren (complications)</term><term>Vieillissement (MeSH)</term><term>Xérostomie (étiologie)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cranial Irradiation</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Glandes salivaires</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Salivary Glands</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Sjogren's Syndrome</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Salive</term><term>Syndrome de Gougerot-Sjögren</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Irradiation crânienne</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Xerostomia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term><term>Salivary Glands</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glandes salivaires</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Xérostomie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aging</term><term>Drug-Related Side Effects and Adverse Reactions</term><term>Female</term><term>Humans</term><term>Male</term><term>Salivation</term><term>Secretory Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Débit sécrétoire</term><term>Effets secondaires indésirables des médicaments</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Salivation</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Vieillissement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is often assumed that salivary secretion reduces with age. About 25% of the elderly suffer from oral dryness and related complaints. Nevertheless, data on stimulated salivary flow rate in healthy elderly revealed no significant age-related decrease other than a slight decrease of the secretion from the (sero)mucous glands under conditions of minimal or extended stimulation. With regard to salivary gland morphology and composition of saliva, age-related changes have been reported in healthy individuals, too. With increasing age, the number of acini reduces and the amount of fatty and fibrous tissue increases. Moreover, animal studies revealed that the synthesis of proteins is reduced by 60% in advanced years. These data indicate that changes might occur in concentration and/or activity of the organic components of saliva. In human studies, the concentration of sIgA in labial saliva and the concentrations of high-molecular and low-molecular mucins in mucous saliva appeared to be reduced with age. Since sIgA and mucins are important in the immunologic and non-immunologic defense of the oral cavity, both defense systems are reduced in healthy elderly. Analysis of these data suggests that the oral soft tissues may become somewhat more susceptible to environmental factors due to a reduction of the immunological and non-immunological defense systems.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9084322</PMID><DateCompleted><Year>1997</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0275-1879</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>3</Issue><PubDate><MedlineDate>1996 May-Jun</MedlineDate></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>Aging and saliva: a review of the literature.</ArticleTitle><Pagination><MedlinePgn>95-103</MedlinePgn></Pagination><Abstract><AbstractText>It is often assumed that salivary secretion reduces with age. About 25% of the elderly suffer from oral dryness and related complaints. Nevertheless, data on stimulated salivary flow rate in healthy elderly revealed no significant age-related decrease other than a slight decrease of the secretion from the (sero)mucous glands under conditions of minimal or extended stimulation. With regard to salivary gland morphology and composition of saliva, age-related changes have been reported in healthy individuals, too. With increasing age, the number of acini reduces and the amount of fatty and fibrous tissue increases. Moreover, animal studies revealed that the synthesis of proteins is reduced by 60% in advanced years. These data indicate that changes might occur in concentration and/or activity of the organic components of saliva. In human studies, the concentration of sIgA in labial saliva and the concentrations of high-molecular and low-molecular mucins in mucous saliva appeared to be reduced with age. Since sIgA and mucins are important in the immunologic and non-immunologic defense of the oral cavity, both defense systems are reduced in healthy elderly. Analysis of these data suggests that the oral soft tissues may become somewhat more susceptible to environmental factors due to a reduction of the immunological and non-immunological defense systems.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vissink</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spijkervet</LastName><ForeName>F K</ForeName><Initials>FK</Initials></Author><Author ValidYN="Y"><LastName>Van Nieuw Amerongen</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="Y">Aging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016371" MajorTopicYN="N">Cranial Irradiation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064420" MajorTopicYN="N">Drug-Related Side Effects and Adverse Reactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012469" MajorTopicYN="N">Salivary Glands</DescriptorName><QualifierName UI="Q000033" MajorTopicYN="Y">anatomy & histology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012472" MajorTopicYN="N">Salivation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012636" MajorTopicYN="N">Secretory Rate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012859" MajorTopicYN="N">Sjogren's Syndrome</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014987" MajorTopicYN="N">Xerostomia</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>59</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9084322</ArticleId><ArticleId IdType="doi">10.1111/j.1754-4505.1996.tb00842.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Spijkervet, F K" sort="Spijkervet, F K" uniqKey="Spijkervet F" first="F K" last="Spijkervet">F K Spijkervet</name><name sortKey="Van Nieuw Amerongen, A" sort="Van Nieuw Amerongen, A" uniqKey="Van Nieuw Amerongen A" first="A" last="Van Nieuw Amerongen">A. Van Nieuw Amerongen</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Vissink, A" sort="Vissink, A" uniqKey="Vissink A" first="A" last="Vissink">A. Vissink</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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